Chemical Genomics of Tuberculosis
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Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes


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New antibiotics are needed to combat rising resistance, with new Mycobacterium tuberculosis (Mtb) drugs of highest priority. We developed a novel strategy termed PROSPECT (PRimary screening Of Strains to Prioritize Expanded Chemistry and Targets) in which we screen compounds against pools of strains depleted for essential bacterial targets.
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Citation:
Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez J, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, Golas A, Guinn KM, Kennedy S, Korn R, McConnell JA, Moss CE, Murphy KC, Nietupski R, Papavinasasundaram KG, Pinkham JT, Pino PA, Proulx MK, Ruecker N, Song N, Thompson M, Trujillo C, Wakabayashi S, Wallach JB, Watson C, Ioerger TR, Lander ES, Hubbard BK, Serrano-Wu MH, Ehrt S, Fitzgerald M, Rubin EJ, Sassetti CM, Schnappinger D, Hung DT. Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes. Nature, Jun 2019, 571, 72–78
Broad Institute
Eachan O. Johnson
Emily LaVerriere
Mary Stanley
Emma Office
Elisabeth Meyer
Tomohiko Kawate
James Gomez
Nirmalya Bandyopadhyay
Kayla Delano
Joshua Davis
Christina Gallo
Aaron Golas
Sofia Kennedy
Rebecca Korn
Ray Neitupski
Matthew Thompson
Christopher Watson
Eric S. Lander
Brian K. Hubbard
Michael H. Serrano-Wu
Michael Fitzgerald
Deborah T. Hung​
Harvard T. H. Chan School of Public Health
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Rebecca E. Audette
Michelle Gardner
Kristine M. Guinn
Jessica T. Pinkham
Shoko Wakabayashi
Eric J. Rubin
Texas A&M University
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Thomas R. Ioerger
University of Massachusetts Medical School
Caitlin E. Moss
Kenan C. Murphy
Kadamba G. Papavinasasundaram
Megan K. Proulx
Christopher M. Sassetti
Weill Cornell Medical College
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Natalia Betancourt
Israel Da Silva
Jennifer A. McConnell
Paula A. Pino
Nadine Ruecker
Naomi Song
Carolina Trujillo
Joshua B. Wallach
Sabine Ehrt
Dirk Schnappinger

Contact us

Broad Institute, 
415 Main St, 
​Cambridge, 
MA 02142 USA
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dhung {at} broadinstitute.org
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Funding

Bill and Melinda Gates Foundation
Broad Institute Tuberculosis Donor group and the Pershing Foundation
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